【摘 要】
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Natural killer cell receptors (NKRs) are membrane proteins that provide specificity to immune cell responses in either an activating or inhibitory fashion.There are two major families of NKRs: NKRs th
【机 构】
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Robert Wood Johnson Medical School-UMDNJ USA
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Natural killer cell receptors (NKRs) are membrane proteins that provide specificity to immune cell responses in either an activating or inhibitory fashion.There are two major families of NKRs: NKRs that share homology with C-type lectins and Killer-cell Ig-like receptors (KIRs), which include 2B4.In the present study, we provide evidence that 2B4 is a major biomarker for immune cells of the gut mucosa in mice and humans.2B4 is expressed by the vast majority of hematopoietic cells in the small intestine and colon (~ 80%), but not in the peripheral immune organs (< 5%).
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