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T-type calcium channels (Cav3.1, Cav3.2 and Cav3.3) make one of the families of the voltage-gated calcium channels (VGCC).T-type channels are distinct from other VGCC types in that they are activated at very negative voltages (activation threshold near-60 mV) Thus, in excitable cells T-type channel activity contributes to the control of excitability by setting up an action potential firing threshold.Pharmacological evidence indicates that the T-type calcium channels are expressed in the receptive fields of peripheral sensory neurons, suggesting that they may play;an important role in nociception.