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  5. TRPC5 is essential for p-glycoprotein induction in drug-resistance cancer cells

TRPC5 is essential for p-glycoprotein induction in drug-resistance cancer cells

来源 :The 4th International Ion Channel Conference(第四届国际离子通道会议) | 被引量 : 0次 | 上传用户：dousansan33
【摘 要】
：
Tumor cells develop multidrug resistance during chemotherapy.An attractive strategy to overcome this resistance is to suppress P-glycoprotein (P-gp), which is overproduced in cancer cells to pump cyto
【作 者】
：
Xin Ma Yanfei Cai Dongxu He Leung Chan Jian Jin Xiaoqiang Yao 
【机 构】
：
Jiang-Nan University;Chinese University of Hong Kong
【出 处】
：
The 4th International Ion Channel Conference(第四届国际离子通道会议)
【发表日期】
：
2013年2期
【关键词】
：
TRPC5 multidrug resistance 
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Tumor cells develop multidrug resistance during chemotherapy.An attractive strategy to overcome this resistance is to suppress P-glycoprotein (P-gp), which is overproduced in cancer cells to pump cytotoxic drugs from cells.In the present study,we found that the Ca2+-permeable channel TRPC5 was overproduced together with P-gp in the adriamy-cin-resistant breast cancer cell line MCF-7/ADM.Suppressing TRPC5 activity/expression reduced the P-gp induction and caused a remarkable reversal of adriamycin resistance in these cells.
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