Splicing isoforms of Fibroblast Growth Factor Homologous Factors specifically modulate sodium channe

来源 :The 4th International Ion Channel Conference(第四届国际离子通道会议) | 被引量 : 0次 | 上传用户：zhanranran

【摘要】

：

【作者】

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Chuan Wang Bin Shan Chaojian Wang Hailin Zhang Geoffrey S.Pitt

【机构】

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Department of Pharmacology, Hebei Medical University, Shijiazhuang, China, 050017

【出处】

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The 4th International Ion Channel Conference(第四届国际离子通道会议)

【发表日期】

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2013年2期

【关键词】

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FHF Nav channel modulation

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Fibroblast growth factor homologous factors (FHFs) 1-4, which further include several splicing variants, regulate voltage-gated sodium (Nav) channels.A human missense mutation in FHF4 or transgenic mice lacking FHF4 causes ataxia.FHF2 conditional knockout mice exhibit neuronal migration defects and weakened learning and memory.Knockdown FHF2 in cardiomyocytes induces slowed cardiac conduction velocity by altering Nav1.5 function.

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Splicing isoforms of Fibroblast Growth Factor Homologous Factors specifically modulate sodium channe

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