Novel TMEM16F Channel, Lipid Scrambling and Blood Coagulation

来源 :The 4th International Ion Channel Conference(第四届国际离子通道会议) | 被引量 : 0次 | 上传用户：dacong966963

【摘要】

：

【作者】

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Huanghe Yang Lily Yeh Jan Andrew Kim Tovo David Taihao Jin Jason Tien Fen Huang Tong Cheng Shaun Coughlin Yuh Nung Jan

【机构】

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University of California, San Francisco, USA

【出处】

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The 4th International Ion Channel Conference(第四届国际离子通道会议)

【发表日期】

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2013年2期

【关键词】

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TMEM16 channels Lipid Scrambling Ca2+-activated nonselective cation channels Ca2

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Collapse of membrane lipid asymmetry is a hallmark of blood coagulation.TMEM16F of the TMEM16 family that includes TMEM16A/B Ca2+-activated C1 channels (CaCCs) is linked to Scott syndrome with deficient Ca2+-dependent lipid scrambling.We generated TMEM 16F knockout mice that exhibit bleeding defects and protection in an arterial thrombosis model associated with platelet deficiency in Ca2+-dependent phosphatidylserine exposure and procoagulant activity and lack a Ca2+-activated cation current in the platelet precursor megakaryocytes.Heterologous expression of TMEM16F generates a small-conductance Ca2+-activated nonselective cation (SCAN) current with subpicosiemens single-channel conductance rather than a CaCC.

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Novel TMEM16F Channel, Lipid Scrambling and Blood Coagulation

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