Exogenous basic fibroblast growth factor inhibits endoplasmic reticulum stress induced apoptosis and

• 作 者: WANGZhou-guang;ZHANGXie;LIRui;ZHANGChao;ZHANGHong-yu;
• 机 构: School of Pharmacy, Key Laboratory of Biotechnology and Pharmaceutical Engineering, Wenzhou Medical
• 出 处: 第十六届全国神经精神药理学学术会议
• 发表日期: 2014年期

　　OBJECTIVE To investigate the mechanism of endoplasmic reticulum stress (ERS)-induced apoptosis as well as the protective action of basic fibroblast growth factor (bFGF) both in vivo and in vitro.RESULTS ERS induced apoptosis was involved in the injuries of spinal cord injury (SCI) model rat.bFGF administration improved the recovery and increased the survival of neurons in spinal cord lesions in model rat.The protective effect of bFGF is related to the inhibition of CHOP, GRP78 and caspase12, which are ER stress-induced apoptosis response proteins.bFGF administration also increased the survival of neurons and the expression of growth-associated protein 43 (GAP43), which is related to neural regeneration.The protective effect of bFGF is related to the activation of downstream signals, PI3K/Akt/GSK-3b and ERK1/2, especially in the ER stress cell model.CONCLUSION This is the first study to illustrate that the role of bFGF in SCI recovery is related to the inhibition of ER stress-induced cell death via the activation of downstream signals.Our work also suggested a new trend for bFGF drug development in central neural system injuries, which are involved in chronic ER stress-induced apoptosis.