【摘 要】
：
To improve the intracellular drug release and anticancer efficacy in cancer therapy, in the present study, a pH and redox dual-sensitive biodegradable micellar system was developed for paclitaxel (PTX
【机 构】
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State Key Laboratory of Quality Research in Chinese Medicine,Institute of Chinese Medical Sciences,U
【出 处】
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2014年中国药物制剂大会——中国药学会药剂专业委员会年会、第六届亚洲阿登制药技术研讨会暨国际控释协会中国分会年会
论文部分内容阅读
To improve the intracellular drug release and anticancer efficacy in cancer therapy, in the present study, a pH and redox dual-sensitive biodegradable micellar system was developed for paclitaxel (PTX) delivery based on the self-assembly of D-α-tocopheryl polyethylene glycol 1000-SS-poly (β-amino ester) (TPGS-SS-PBAE) copolymer.TPGS-SS-PBAE copolymer was first synthesized via Michael addition polymerization of diacrylate and piperazine in the presence of TPGS-SS-diacrylate macromonomer.
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