Overcoming drug resistance of tumor cells by altering intracellular distribution of doxorubicin

来源 :2014年中国药物制剂大会——中国药学会药剂专业委员会年会、第六届亚洲阿登制药技术研讨会暨国际控释协会中国分会年会 | 被引量 : 0次 | 上传用户：hlly369

【摘要】

：

【作者】

：

Min Han Hui-Na Liu Ming-Yi Huangfu Zhi-Lan Chen Afsaneh Lavasanifar Jian-Qing Gao

【机构】

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College of Pharmaceutical Sciences,Zhejiang University,Hangzhou 310058,China

【出处】

：

2014年中国药物制剂大会——中国药学会药剂专业委员会年会、第六届亚洲阿登制药技术研讨会暨国际控释协会中国分会年会

【发表日期】

：

2014年8期

【关键词】

：

drug resistance intracellular distribution mitochondrion nucleus Small-interferi

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　　Drug resistance is one of the critical reasons leading to tailure in chemotherapy.Enormous studies have been focused on increasing intracellular drug accumulation through inhibiting P-glycoprotein (Pgp).In this study, doxorubicin (DOX) was delivered specifically to mitochondria by conjugating to a lipophilic triphenylphosphonium (TPP), or to nucleus by a polyamidoamine (PAMAM) dendrimers functionalized with a polysaccharide hyaluronic acid (HA) containing major vault protein (MVP) targeted small-interfering RNA(MVP-siRNA).

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Overcoming drug resistance of tumor cells by altering intracellular distribution of doxorubicin

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