Novel 4-Arm-PEG-TPGS Amphiphilic Copolymer Micelles Loading Paclitaxel: Preparation, Characterizatio

来源 :2014年中国药物制剂大会——中国药学会药剂专业委员会年会、第六届亚洲阿登制药技术研讨会暨国际控释协会中国分会年会 | 被引量 : 0次 | 上传用户：lilunyi

【摘要】

：

【作者】

：

Yupei Wu Songwei Tan Xiangting Zhuang Yuling Bao Tingting Wu Zhiping Zhang

【机构】

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Tongji School of Phamarcy,Tongji Medical College,Huazhong University of Science & Technology,Wuhan 4

【出处】

：

2014年中国药物制剂大会——中国药学会药剂专业委员会年会、第六届亚洲阿登制药技术研讨会暨国际控释协会中国分会年会

【发表日期】

：

2014年8期

【关键词】

：

4-Arm-PEG-TPGS paclitaxel micelle

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　　Over the past few decades, the exploitation of branched PEG modified biocompatible and biodegradable polymers has received considerable attention.These polymers containing both hydrophobic and hydrophilic segments are of particular interest for biomedical applications, such as drug delivery.In this study, new amphiphilic block copolymers, 4-arm poly(ethylene glycol)-block-tocopheryl polyethylene glycol succinate (4-arm-PEG-C-C-TPGS、 4-arm-PEG-S-S-TPGS) with different molecular weight of 4-arm-PEG (5K、 10K、 20K) were synthesized to as potential paclitaxel (PTX) carriers.

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