Small GTPase RBJ mediates nuclear entrapment of MEK1/2 in tumor progression

来源 :22nd Asia Pacific Cancer Conference(第22届亚太抗癌大会) | 被引量 : 0次 | 上传用户：wmwanll

【摘要】

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【作者】

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Tao-Tong Chen Chao-Feng Han Qiu-Yan Liu Yan Gu Long Cui Ming-Hua Zhu wei-Qiang Zheng Xue-Tao Cao Ming-Jin Yang Zhou Yu Song-Qing Tang Chen Wang Xu-Hui Zhu Jun Guo Jin Hou Hai-Bo Liu

【机构】

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National Key Laboratory of Medical Immunology and Institute of Immunology,Second Military Medical Un

【出处】

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22nd Asia Pacific Cancer Conference(第22届亚太抗癌大会)

【发表日期】

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2013年7期

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　　Objective: The Ras superfamily is divided into five principal subfamilies, namely, Ras, Rho, Rab, ADP-ribosylation factor, and Ran.These proteins have important functions in diverse cellular and developmental events.RBJ, which is a newly identified member of the sixth subfamily of Ras-related small GTPase,was cloned independently (GenBank No.AF178983, referred to as RabJ).RBJ has been reported by other laboratories, but biological and functional data for RBJ are insufficient.Most Ras-related small GTPases are involved in the regulation of tumorigenesis and tumor progression.

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Small GTPase RBJ mediates nuclear entrapment of MEK1/2 in tumor progression

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