【摘 要】
：
Recent studies identified a group of structurally diverse muhifunctional host proteins rapidly released following pathogen challenge or cell injury and, most importantly, able to chemotactically recru
【机 构】
：
Laboratory of Molecular Immunoregulation,CIP,CCR,NCI Frederick
【出 处】
：
22nd Asia Pacific Cancer Conference(第22届亚太抗癌大会)
论文部分内容阅读
Recent studies identified a group of structurally diverse muhifunctional host proteins rapidly released following pathogen challenge or cell injury and, most importantly, able to chemotactically recruit and activate dendritic antigen-presenting cells.These potent immuno-stimulants, called alarmins, including defensins, cathelicidin (LL37), eosinophil-derived neurotoxin(EDN), lactoferrin (LF), granulysin, high-mobility group box protein 1 (HMGB1), and HMGN1 served as early warning signals to activate innate and adaptive immune systems.
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