抗肿瘤新药羰铂的临床前研究

来源 :2015年全国药物化学学术会议暨第五届中英药物化学学术会议 | 被引量 : 0次 | 上传用户：tonnyliu2042

【摘要】

：

顺铂自1978年上市以来，一直作为一线抗肿瘤药物被广泛临床使用。相关机制研究表明，顺铂及其类似物主要通过与DNA相互作用抑制肿瘤细胞的生长，但因水溶性差且与含硫生物分子作用产生的毒性和耐药性也限制了其应用。随后出现的第二代铂药物卡铂虽然毒性较顺铂低，不过其抗癌活性也显著降低。

【作者】

：

苟少华

【机构】

：

东南大学化学化工学院;江苏省生物药物高技术研究重点实验室,南京市江宁区,211189

【出处】

：

2015年全国药物化学学术会议暨第五届中英药物化学学术会议

【发表日期】

：

2015年3期

【关键词】

：

铂配合物功能羧酸根抗肿瘤羰铂

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抗肿瘤新药羰铂的临床前研究

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