P-MMAE,a novel antibody-drug conjugate,is highly effective against primary HER2 overexpressing gastr

来源 :2015年全国药物化学学术会议暨第五届中英药物化学学术会议 | 被引量 : 0次 | 上传用户：ribb5619

【摘要】

：

Gastric cancer is one of the most frequent human malignancies and the second leading cause of cancer-related death in the world.Human epidermal growth factor receptor 2(HER2)is overexpressed in~20%of

【作者】

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Tao Meng Lanping Ma Xin Wang Hongli Peng Ting Yu Yongliang Zhang Lin Chen Yiyi Chen Jingkang Shen

【机构】

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State Key Laboratory of Drug Research,Shanghai Institute of Materia Medica,Chinese Academy of Scienc

【出处】

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2015年全国药物化学学术会议暨第五届中英药物化学学术会议

【发表日期】

：

2015年3期

【关键词】

：

Pertuzumab Kadcyla P-MMAE Gastric cancer Her2

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　　Gastric cancer is one of the most frequent human malignancies and the second leading cause of cancer-related death in the world.Human epidermal growth factor receptor 2(HER2)is overexpressed in~20%of gastric cancers.[1] A number of new HER2 targeted compounds such as trastuzumab,pertuzumab,lapatinib,which are currently undergoing phase Ⅱ and Ⅲ clinical testing.[1] Compare to the currently approved standard treatment.

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P-MMAE,a novel antibody-drug conjugate,is highly effective against primary HER2 overexpressing gastr

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