Gastric cancer is one of the most frequent human malignancies and the second leading cause of cancer-related death in the world.Human epidermal growth factor receptor 2(HER2)is overexpressed in~20%of
Preventing of HIV entry into human host cells is an attractive way to controlling viral infection and replication,CCR5 is a coreceptor for entry of macrophage-tropic(R5)HIV-1 into host cells [1].
Senile Aβ plaques have been widely found in post-mortem brains of Alzheimers disease(AD)patients and are viewed as one of the principal hallmarks of the disease[1].A deposits are therefore thought to
As one of the most important members of the poly(ADP-ribose)polymerases(PARPs)families,PARP1 is a critical DNA repair enzyme in the base excision repair pathway.Inhibition of PARP1 is a potential "syn
Multi-substituted pyrroles and pyridines are important scaffolds in medicinal chemistry and organic chemistry due to their prevalence in numerous natural products and synthetic compounds.
In the last few years,a large structural variety of N-aryl-salicylamide derivatives as the potential EGFR PTK inhibitors have been synthesized and studied,which showed efficient antitumor activity1-5.