【摘 要】
：
Non-alcoholic fatty liver disease (NAFLD) has become a global public health issue, however the exact pathogenesis has not been elucidated and there is no ideal drugs for NAFLD.Akebia saponin D is a ty
【机 构】
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Beijing Chao-yang Hospital China
【出 处】
：
2013第三届内分泌与代谢大会暨2013第二届糖尿病大会
论文部分内容阅读
Non-alcoholic fatty liver disease (NAFLD) has become a global public health issue, however the exact pathogenesis has not been elucidated and there is no ideal drugs for NAFLD.Akebia saponin D is a typical bioactive triterpenoid saponin isolated the rhizome ofDipsacus asper Wall.This study was aimed to evaluate the protective effects and mechanisms of ASD in NAFLD.C57BL/6-Lepob/ob mice were used as the fatty liver animal models.Ob/ob mice received daily intraperitoneal injections of ASD for 4 weeks.Ob/ob mice showed a significant increase in the levels of LDL, TG, AST, ALT and a significant decrease in the activities of HDL in plasma and liver.Histopathological examination of the liver in ob/ob mice contained larger vesicular structures consistent with macrovesicular steatosis.
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