Serum IGF-1 is Insufficient to Restore Body Size in the Absence of the Growth Hormone Receptor

来源 :2013第三届内分泌与代谢大会暨2013第二届糖尿病大会 | 被引量 : 0次 | 上传用户：woshi52031

【摘要】

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【作者】

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Yingjie Wu

【机构】

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The Mount Sinai School of Medicine USA

【出处】

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2013第三届内分泌与代谢大会暨2013第二届糖尿病大会

【发表日期】

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2013年12期

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　　States of growth hormone (GH) resistance, such those observed in Larons dwarf patients, are characterized by mutations in the GH receptor (GHR), decreased serum and tissue IGF-1 levels, impaired glucose tolerance, and impaired skeletal acquisition.IGF-1 replacement therapy in such patients increases growth velocity but does not normalize growth.Herein we combined the GHresistant (GHR knockout, GHRKO) mouse model with mice expressing the hepatic Igf-1 transgene (HIT) to generate the GHRKO-HIT mouse model.

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Serum IGF-1 is Insufficient to Restore Body Size in the Absence of the Growth Hormone Receptor

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