【摘 要】
：
The germinal center (GC) reaction supports affinity-based B-cell competition and generates high-affinity bone-marrow plasma cells (BMPC).ICOS and ICOSL have long been know as crucial for GC response,
【机 构】
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Tsinghua-Peking Center for Life Sciences, Laboratory of Dynamic Immunobiology, School of Medicine, T
【出 处】
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中国免疫学会第九届全国免疫学学术大会
论文部分内容阅读
The germinal center (GC) reaction supports affinity-based B-cell competition and generates high-affinity bone-marrow plasma cells (BMPC).ICOS and ICOSL have long been know as crucial for GC response, although the underlying mechanism has not always been clear.In particular, a prevailing view was that ICOS co-stimulation programs the follicular T-helper (Tfh) cell differentiation and thereby control the GC formation.
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