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  5. Impaired anti-fibrotic activity of NK cells is dependent on hepatic stellate cells-derived TGF-β and

Impaired anti-fibrotic activity of NK cells is dependent on hepatic stellate cells-derived TGF-β and

来源 :中国免疫学会第九届全国免疫学学术大会 | 被引量 : 0次 | 上传用户：chenzenghua
【摘 要】
：
Natural killer (NK) cells have been implicated in inducing fibrosis remission in mice model;however, their roles in fibrotic progression remain to be elucidated in patients with liver fibrosis (LC).Th
【作 者】
：
Juanjuan Zhao Zheng Zhang Fu-Sheng Wang 
【机 构】
：
Research Center for Biological Therapy, Beijing 302 Hospital, Beijing, China
【出 处】
：
中国免疫学会第九届全国免疫学学术大会
【发表日期】
：
2014年8期
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Natural killer (NK) cells have been implicated in inducing fibrosis remission in mice model;however, their roles in fibrotic progression remain to be elucidated in patients with liver fibrosis (LC).The present study aims to identify the role of NK cells in liver cirrhosis with chronic HBV infection and relevant mechanisms.We comprehensively characterized frequency, phenotypes, function and the relevant regulatory mechanisms of peripheral and intrahepatic NK cells in 50 chronic hepatitis B (CHB) patients and 68 HBV-associated LC patients as well as 35 healthy subjects (HC).
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