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CD30 ligand (CD30L, CD153), a member of the TNF superfamily, and its receptor CD30 are important for differentiation and activation of CD4+ Th1 7 cells.In the present report, we demonstrate that the IL-17A-producing gd T cells normally developed in the fetal thymus, whereas Vγ1-Vγ4-γδ T cells expressed Vγ6 gene transcript, selectively decreased in mucosa-associated tissues in na(i)ve CD30KO or CD30LKO mice.Moreover, CD30 and CD30L were expressed preferentially by Vγ1-Vγ4-γδ T cells in na(i)ve mice.