【摘 要】
：
研究背景:髓系来源的抑制性细胞(myeloid-derived suppressor cells,MDSC)在机体中发挥免疫抑制功能.有关MDSC的研究主要集中于肿瘤领域,其在自身免疫病,尤其是类风湿关节炎RA中的作用罕有报道.目的:该研究拟通过临床病人标本以及动物模型,系统性探讨MDSC在RA发病中的作用及具体机制.方法:通过流式细胞术检测16例正常人、35例RA病人(包括22例高疾病活动度(D
【机 构】
：
北京大学人民医院风湿免疫研究所 Virginia Commonwealth University
【出 处】
：
中国免疫学会第九届全国免疫学学术大会
论文部分内容阅读
研究背景:髓系来源的抑制性细胞(myeloid-derived suppressor cells,MDSC)在机体中发挥免疫抑制功能.有关MDSC的研究主要集中于肿瘤领域,其在自身免疫病,尤其是类风湿关节炎RA中的作用罕有报道.目的:该研究拟通过临床病人标本以及动物模型,系统性探讨MDSC在RA发病中的作用及具体机制.方法:通过流式细胞术检测16例正常人、35例RA病人(包括22例高疾病活动度(DAS28＞5.1)和13例低疾病活动度(DAS28≤5.1) RA病人)以及15例OA病人外周血中MDSC的比例;并同时检测15例OA病人以及23例RA病人关节液中MDSC的比例,探讨其与临床症状的关联.进而构建CIA动物模型,通过流式细胞术检测其外周血、脾脏、骨髓、爪子中的MDSC以及Th17细胞的比例,并与关节炎病理评分进行相关性分析.功能试验方面,通过MDSC-na(i)ve T细胞共培养,在Th17细胞极化条件下探讨MDSC对Th17细胞分化的促进作用.最后,体内清除以及过继转移MDSC,观察其对CIA的影响.
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