Positive association of genetic variations in the phospholipase C-like 1 gene region with polymyosit

来源 :中国免疫学会第九届全国免疫学学术大会 | 被引量 : 0次 | 上传用户：true51

【摘要】

：

【作者】

：

Si Chen Qian Wang Yuan Li Ping Li Chan-Yuan Wu Zi-Yan Wu Qing-Jun Wu Fei Sun Jing Li Wei-Jie Zheng Chui-Wen Deng Feng-Chun Zhang Yong-Zhe Li

【机构】

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Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese A

【出处】

：

中国免疫学会第九届全国免疫学学术大会

【发表日期】

：

2014年8期

【关键词】

：

dermatomyositis polymyositis phospholipase C-like 1 gene polymorphism associatio

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Objective: PLCL1 (phospholipase C-like 1) encodes an inositol 1,4,5-trisphosphate (IP3) binding protein that can inhibit IP3 mediated calcium signaling.Yet the accurate mechanism by which PLCL1 played in the pathogenesis of idiopathic inflammatory myopathies (IIMs) is unclear.One genome-wide association studies (GWAS) have designated PLCL1 as a potential risk factor for dermatomyositis (DM).In our study, we investigated whether PLCL1 polymorphisms could be associated with IIMs in Chinese Han.

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Positive association of genetic variations in the phospholipase C-like 1 gene region with polymyosit

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