低氧对RA滑膜成纤维样细胞表达G6PI和HIF-1α的影响

来源 :中国免疫学会第九届全国免疫学学术大会 | 被引量 : 0次 | 上传用户：xxak48

【摘要】

：

目的:类风湿性关节炎(RA)患者的滑膜腔是一个低氧环境.本研究将通过对骨性关节炎(OA)和RA患者的关节滑膜成纤维样细胞(FLS)进行正常氧和低氧培养后,观察FLS表达G6PI和HIF-1α的变化情况.方法:原代培养OA和RA患者的滑膜成纤维细胞,分别在正常氧和3％氧环境中培养24小时,Real-time PCR检测G6PI、HIF-1 αmRNA表达水平,Western blot检测G6PI、H

【作者】

：

陆英范列英

【机构】

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同济大学附属东方医院

【出处】

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中国免疫学会第九届全国免疫学学术大会

【发表日期】

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2014年8期

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低氧对RA滑膜成纤维样细胞表达G6PI和HIF-1α的影响

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