Asiatic acid inhibits transforming growth factor-β1-induced collagen expression in keloid fibroblast

来源 :The 12th Meeting of the Asia Pacific Federation of Pharmacol | 被引量 : 0次 | 上传用户：juanzi0666

【摘要】

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【作者】

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Yan YANG Di-fei BIAN Yue DAI

【机构】

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State Key Laboratory of Natural Medicines,Department of Pharmacology of Chinese Materia Medica, Chin

【出处】

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The 12th Meeting of the Asia Pacific Federation of Pharmacol

【发表日期】

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2013年4期

【关键词】

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asiatic acid keloid fibroblasts TGF-β/Smad pathway PPAR-γ

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Aim: To investigate the effects of asiatic acid (AA) on cell proliferation, invasion and collagen expression in TGF-β1-stimulated keloid fibroblasts and the underlying mechanisms.Methods: 5-ethynyl-2-deoxyuridine (EdU) incorporation assay, transwell invasion assay, enzyme-linked immunosorbent assay, Western blot, quantitive polymerase chain reaction and RNA interference assay were performed.

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Asiatic acid inhibits transforming growth factor-β1-induced collagen expression in keloid fibroblast

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