Theraputic effect of rhTNFR:Fc on rats with adjuvant induced arthritis via attenuating inflammatory

来源 :The 12th Meeting of the Asia Pacific Federation of Pharmacol | 被引量 : 0次 | 上传用户：yclmq

【摘要】

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【作者】

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Yu-jing WU Ai-wu ZHOU Li-hua LIU Wei WEI Ling-ling ZHANG Qing-tong WANG Yun-fang ZHANG Shan-shan SONG Bei HUANG Jing-yu CHEN Hua-xun WU Yan CHANG

【机构】

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Institute of Clinical Pharmacology, Anhui Medical University, Key Laboratory of Antiinflammatory and

【出处】

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The 12th Meeting of the Asia Pacific Federation of Pharmacol

【发表日期】

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2013年4期

【关键词】

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adjuvant arthritis inflammation TNF-α macrophage cytokines T lymphocytes

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Aim: To examine the effects of rhTNFR:Fc on disease progression, joint inflammation, bone destruction and the production of inflammatory mediators in a rat model of adjuvant induced arthritis (AA).Methods: AA was induced by complete Freund adjuvant.AA rats with experimental arthritis were randomly separated into different groups and then treated with rhTNFR:Fc (1, 3, and 9 mg/ kg), or IgG-Fc (9 mg/kg), subcutaneously after immurization every 3 d for a total of 15 d.

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Theraputic effect of rhTNFR:Fc on rats with adjuvant induced arthritis via attenuating inflammatory

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