Salvianolic acid A protects against diabetic nephropathy in type 2 diabetes

来源 :The 12th Meeting of the Asia Pacific Federation of Pharmacol | 被引量 : 0次 | 上传用户：aspiis6sql

【摘要】

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【作者】

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Xiu-ying YANG Gui-fen QIANG Xiao-yu BAI Hai-guang YANG Li ZHANG Guan-hua DU

【机构】

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Beijing Key Laboratory of Drug Targets Identification and Drug Screening,Institute of Materia Medica

【出处】

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The 12th Meeting of the Asia Pacific Federation of Pharmacol

【发表日期】

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2013年4期

【关键词】

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salvianolic acid A type 2 diabetes diabetic nephropathy

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Aim: Salvianolic acid A (SalA) is one of the main water-soluble active components in Salvia miltiorrhizae.The aim of this study was to investigate the effects of SalA on prevention and treatment of diabetic nephropathy.Methods: Spontaneously type 2 diabetic mice (KK/Upj-Ay/J) were used in the experiment.The mice with blood glucose above 8 mmol/L were chosen and randomly divided into 4 groups: diabetic control; SalA treatment groups (0.4, 1.3, and 4 mg/kg); age matched C57BL/6 mice were empolyed as normal control.SalA was oral administrated daily for 4 months.

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Salvianolic acid A protects against diabetic nephropathy in type 2 diabetes

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