【摘 要】
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Innate Lymphoid Cells(ILC)were newly discovered cells that existed between innate and adaptive immunity,which can be divided into ILC1,ILC2 and ILC3.It had been reported that ILC3s can influence the i
【机 构】
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Institute of Immunology,Zhejiang University School of Medicine,Hangzhou 310058,China
【出 处】
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中国生物化学与分子生物学会2016年全国学术会议
论文部分内容阅读
Innate Lymphoid Cells(ILC)were newly discovered cells that existed between innate and adaptive immunity,which can be divided into ILC1,ILC2 and ILC3.It had been reported that ILC3s can influence the inflammatory bowel disease through the secretion of cytokines and T cell depended immunotolerence.Though the Interferon Regulator Factor 4(IRF4)was essential in the differentiation and cytokine production of T help cells,its function and molecular mechanism in intestinal ILCs had not been reported yet.We therefore generated IRF4 conditional knockout mice in which the function of IRF4 gene was conditionally disrupted by CD2Cre transgene.Our data showed that after the deletion of IRF4,ILC3s showed impaired development and secretion of cytokines.In the model of C.rodentium infection,IRF4 deficiency impaired ILC3 responses to bacterial infection.Thus,we found that IRF4 was of importance in the ILC3 mediated bacterial infected bowel disease.
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