【摘 要】
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Purpose:Cone-beam x-ray luminescence computed tomography(CB-XLCT)opens new possibilities to perform molecular imaging with x-ray.The spatial resolution of CB-XLCT was limited because of severe ill-pos
【机 构】
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Department of Biomedical Engineering,Fourth Military Medical University,Xi'an,Shaanxi 710032,China
【出 处】
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The 15th Asia-Oceania Congress of Medical Physics (AOCMP2015
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Purpose:Cone-beam x-ray luminescence computed tomography(CB-XLCT)opens new possibilities to perform molecular imaging with x-ray.The spatial resolution of CB-XLCT was limited because of severe ill-posed problem in the reconstruction.In this paper,an excitation-resolved method was used to locate two adjacent nanophosphors of different concentrations to improve the imaging quality.The imaging model and reconstruction method are described.Methods:In the proposed method,x-ray sources of multiband voltages(50,60,70,and 80 kV)were adopted to excite the nanophosphors and the optical images were acquired by the CCD,meanwhile the structural information can be obtained by the traditional x-ray CT imaging.The diffusion approximation model was used to describe the photon propagation,and the nanophosphor distributions were reconstructed with the algebraic reconstruction technique(ART).As nanophosphors of different concentrations show different excitation behaviors under multiband x-ray source voltages,multivariate image analysis were used to deal with the reconstructed results in our work.Results:Physical phantom experiments were carried out to test the proposed method.The experimental results showed that the two adjacent tubes filled with nanophosphors of different concentrations can be located using the proposed method.Conclusions:The adjacent nanophosphors can be resolved by using the multiband imaging scheme combined with multivariate image analysis.The proposed excitation-resolved cone beam XLCT method was validated by physical experiments in the performance of improving imaging quality.
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