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  5. Oxystress Induced Antitumor Therapy Using Hydrogen Peroxide Generated by Tumor-targeted Delivery of

Oxystress Induced Antitumor Therapy Using Hydrogen Peroxide Generated by Tumor-targeted Delivery of

来源 :BIT Life Sciences 1st Annual World Cancer Congess-2008(2008中 | 被引量 : 0次 | 上传用户：softzheng1
【摘 要】
：
Because of their highly cytotoxic nature, reactive oxygen species (ROS), e.g.H2O2, may exert remarkable antitumor potential if they can be selectively delivered into tumors.We thus developed an oxystr
【作 者】
：
Jun Fang Hideaki Nakamura Arun K Iyer Khaled Greish Hiroshi Maeda 
【机 构】
：
Laboratory of Microbiology & Oncology Faculty of Pharmaceutical Sciences Sojo University Japan
【出 处】
：
BIT Life Sciences 1st Annual World Cancer Congess-2008(2008中
【发表日期】
：
2008年12期
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　　Because of their highly cytotoxic nature, reactive oxygen species (ROS), e.g.H2O2, may exert remarkable antitumor potential if they can be selectively delivered into tumors.We thus developed an oxystress dependent antitumor strategy by use of PEG conjugated D-amino acid oxidase (PEG-DAO), which exhibited potent antitumor activity via generating H2O2, by taking advantage of the enhanced permeability and retention (EPR) effect.Along this line,we report here the preparation of PEG-DAO by use of recombinant DAO (rDAO) and its antitumor activity.
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