【摘 要】
：
A pH-responsive and biodegradable polymeric micelle was developed as a tumor-targeting drug and superparamagnetic iron oxide nanoparticle delivery system.The block copolymer was synthesized by a Micha
【机 构】
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Department of Polymer Science and Engineering Sungkyunkwan University Korea
【出 处】
：
BIT Life Sciences 1st Annual World Cancer Congess-2008(2008中
论文部分内容阅读
A pH-responsive and biodegradable polymeric micelle was developed as a tumor-targeting drug and superparamagnetic iron oxide nanoparticle delivery system.The block copolymer was synthesized by a Michael-type step polymerization ofhydrophilic methyl ether poly(ethylene glycol) (MPEG) and pH-responsive and biodegradable poly(β-amino ester), resulting in an amphiphilic MPEG-poly(β-amino ester) block copolymer.This copolymer, which could selfassemble nano-sized mieelles with core-shell structures under aqueous conditions, showed noticeable the pHdependent micellization-demicellization behavior.The micelle core could provide a carrier compartment for hydrophobic agents, and the hydrophilic shell stabilized micelles in blood environment and prolonged circulation time.
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