Cationic charged N-(2-hydroxypropyl) methacrylamide copolymer-based strategy for overcoming the fola

• 作 者: LianLi;QingqingYang;ZhouZhou;JiajuZhong;YuanHuang;
• 机 构: Key Laboratory of Drug Targeting and Drug Delivery System,Ministry of Education,West China School of
• 出 处: 2014年中国药物制剂大会——中国药学会药剂专业委员会年会、第六届亚洲阿登制药技术研讨会暨国际控释协会中国分会年会
• 发表日期: 2014年期

　　Although folate exhibits many advantages over other targeting ligands, it has one major defect: poor water solubility.Once it was conjugated to hydrophilic drug carrier such as N-(2-hy droxypropyl) methacrylamide (HPMA) copolymer, the hydrophobic folate may be buried inside the random polymer coil and not exposed to be accessible to its receptor on the cell surface, thus losing its active targeting ability.