Dry power inhalation of Tetrandrine for improve the efficacy of cisplatin

来源 :2014年中国药物制剂大会——中国药学会药剂专业委员会年会、第六届亚洲阿登制药技术研讨会暨国际控释协会中国分会年会 | 被引量 : 0次 | 上传用户:metoo321
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  In order to evaluate the effect of Tetrandrine (TET) on the anticancer efficacy of cisplatin, dry powder inhahtion of TET (DPI-TET) was prepared.The evaluation of DPI was performed using two types of index including physicochemical properties (morphology, particle size and distribution, hygroscopicity, flowability) and aerosolisation performances (fine particles fraction and emitted dose).DPI was formed by micronized TET and carrier to obtain desired properties.The enhancing mechanism of chemotherapeutic drug in vitro was approached using human lung adenocarcinoma cell lines A549 and drug resistant cell lines A549/DDP.
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