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Objective: To investigate the clinical features and prognostic factors of primary small intestine lymphoma (PSIL).Methods: The clinical data of 48 cases with PSIL were studied retrospectively.All patients received treatment at the Tianjin Medical University Cancer Hospital from January 2002 to February 2012.Survival curves were built using Kaplan-Meier Methods.Log-rank test was used in the univariate analysis.Multivariate analysis was performed using Cox regression model to evaluate the independent prognostic factors.