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Objective: To investigate the role of mucopolysacchride polysulfate cream combined with magnesium sulfate in the prevention of mechanical phlebitis for patients with PICC.Methods: PICC patients were randomly divided into control and experimental groups.Patients in the control group received general knowledge education notes after catheterization.Patients in the experimental group received general knowledge education notes and treatment with mucopolysacchride polysulfate cream combined with magnesium sulfate twice everyday.