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  5. The novel tubulin-targeting agent MT-4 suppresses human ovarian cancer growth In vitro and in vivo

The novel tubulin-targeting agent MT-4 suppresses human ovarian cancer growth In vitro and in vivo

来源 :The 12th Meeting of the Asia Pacific Federation of Pharmacol | 被引量 : 0次 | 上传用户：zhsotanlb
【摘 要】
：
Aims: In this study, the anti-cancer mechanisms of moscatilin(MT-4), have been examined in cisplatin-sensitive ovarian cancer cells (A2780) and multidrug resistance ovarian cancer cells (NCI-ADR-RES).
【作 者】
：
Hui-Chen PAI Shiow-Lin PAN Che-Ming TENG 
【机 构】
：
Phamacological Institute,College of Medicine,National Taiwan University,No.1,Jen-Ai Road,Sec.1,Taipe
【出 处】
：
The 12th Meeting of the Asia Pacific Federation of Pharmacol
【发表日期】
：
2013年4期
【关键词】
：
moscatilin (MT4) resisrance apoptosis ovarian cancer cells anti-cancer 
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Aims: In this study, the anti-cancer mechanisms of moscatilin(MT-4), have been examined in cisplatin-sensitive ovarian cancer cells (A2780) and multidrug resistance ovarian cancer cells (NCI-ADR-RES).Methods: MTT, flow cytometry,tubulin binding assay, and Western blot assay were used.Results: MT-4 inhibited cell viability in both ovarian cancer cells.
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