• 不 限
  • 期刊论文
  • 硕博论文
  • 会议论文
  • 报 纸
  • 英文论文
  2. 您的位置
  3. 首页
  4. 会议论文
  5. Epistasis on Hemagglutinin Contributes Significantly to the Antigenic Evolution of Influenza A(H3N2)

Epistasis on Hemagglutinin Contributes Significantly to the Antigenic Evolution of Influenza A(H3N2)

来源 :第六届全国生物信息学与系统生物学学术大会暨国际生物信息学前沿研讨会 | 被引量 : 0次 | 上传用户：surtacohen1
【摘 要】
：
Background: Influenza A(H3N2) virus causes continuing epidemics in the human society since its emergence in 1968, due to its ability to change its antigenicity frequently through rapid mutations and t
【作 者】
：
彭友松 邓立宗 蒋太交 
【机 构】
：
信息科学与工程学院,湖南大学,长沙,410082 系统医学研究所,苏州
【出 处】
：
第六届全国生物信息学与系统生物学学术大会暨国际生物信息学前沿研讨会
【发表日期】
：
2014年4期
【关键词】
：
epistasis antigenic evolution influenza A(H3N2) virus 
下载到本地 , 更方便阅读
下载此文 赞助VIP
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
　　Background: Influenza A(H3N2) virus causes continuing epidemics in the human society since its emergence in 1968, due to its ability to change its antigenicity frequently through rapid mutations and thus escape the host immunity.Epistasis is reported to influence the antigenicity of the influenza virus.It is prevalent in the evolution of influenza A virus, especially for its surface proteins Hemagglutinin (HA) and Neuraminidase (NA).However, it is still unknown to what extent the epistasis contribute to the antigenic evolution of influenza A virus.
其他文献
Irregular transcriptome reprogramming probably caused embryo developmental failure of interspecies n
Methods: Interspecies somatic cell nuclear transfer (iSCNT) has been regarded as a potential alternative in rescuing highly endangered species and can be used as a model for studying nuclear-cytoplasm
会议
SCNTtranscriptome reprogrammingembryonic genome activationtranscriptional reg
CIRI: An Efficient and Unbiased Algorithm for de novo Circular RNA Identification
Background: Recent studies reveal that circular RNAs (circRNAs) are a novel class of abundant, stable and ubiquitous noncoding RNA molecules in animals, and some of them function as microRNA sponges.A
会议
circular RNARNA-seqpaired chiastic clipping signaltranscriptome
Arm Selection and/or Arm Switching Contribute to Dynamic miRNAome and/or IsomiRome
Background: Many pre-miRNAs have been reported to yield two kinds of mature miRNAs, although the two products, miR-#-5p and miR-#-3p, may vary in expression levels.Arm selection and/or arm switching i
会议
microRNA (miRNA)isomiRisomiR expression divergenceevolutionary divergence
Gene module based regulator inference identifying miR-139 as a tumor suppressor in colorectal cancer
Colorectal cancer is one of the most commonly diagnosed cancer types worldwide.Identifications of the key regulators of the significantly altered biological networks are crucial for understanding the
会议
gene modulemiRNAgene regulationcolorectal cancer
piRNA-mediated cleavage of messenger RNAs and long non-coding RNAs
Background: The piRNA machinery is well known for its role in mediating epigenetic silencing of transposons and recent studies suggest that this function may also involve piRNA-guided cleavage of tran
会议
piRNAMiwi proteinlong non-coding RNAgene regulation
LincSNP: a database of linking disease-associated SNPs to human large intergenic non-coding RNAs
Background: Genome-wide association studies (GWAS) have successfully identified a large number of single nucleotide polymorphisms (SNPs) that are associated with a wide range of human diseases.However
会议
LincRNADisease-associated SNPsGWASNon-coding RNADatabase
Structural bases for conservative Leu (Ile) site of the CD loop induced gating kinetics difference o
Background: Inward-rectifier potassium (Kir) channels conduct K+ ions most efficiently into the cell, which are expressed in a wide variety of cells and involved in many physiological processes.The fu
会议
Inwardly rectifying potassium (Kir)Molecular dynamics simulation (MDS)Conforma
Exploring the pH-Dependent Substrate Transport Mechanism of FocA Using Molecular Dynamics Simulation
Background: FocA belongs to the formate-nitrate transporter family and plays an essential role in the export and uptake of formate in organisms.According to the available crystal structures, the N-ter
会议
formateformic acidFocApH
Regular Patterns of the Structural Disorder Variation of the Same Protein Domains in Different Conte
Background: Intrinsically disordered proteins (IDPs) do not shape into a stable and well-structured three-dimensional fold, while they are biologically active.It has been reported that many domains we
会议
domainstructural disorderevolution
Allosteric sites can be identified based on the residue-residue interaction energy difference
Background: Allosteric drugs, taking an action-at-a-distance mechanism to achieve regulations on the protein functions, have several advantages over conventional orthosteric drugs, including diverse r
会议
allosteric site identificationMM/GBSAenergy decompositionresidue-residue inte