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  5. Regular Patterns of the Structural Disorder Variation of the Same Protein Domains in Different Conte

Regular Patterns of the Structural Disorder Variation of the Same Protein Domains in Different Conte

来源 :第六届全国生物信息学与系统生物学学术大会暨国际生物信息学前沿研讨会 | 被引量 : 0次 | 上传用户：haojianhong
【摘 要】
：
Background: Intrinsically disordered proteins (IDPs) do not shape into a stable and well-structured three-dimensional fold, while they are biologically active.It has been reported that many domains we
【作 者】
：
马冲 杨冬 钟儒刚 贺福初 
【机 构】
：
军事医学科学院放射与辐射医学研究所,北京蛋白质组研究中心,蛋白质组学国家重点实验室,北京,102206;北京工业大学生命科学与生物工程学院,北京,100022
【出 处】
：
第六届全国生物信息学与系统生物学学术大会暨国际生物信息学前沿研讨会
【发表日期】
：
2014年4期
【关键词】
：
domain structural disorder evolution 
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　　Background: Intrinsically disordered proteins (IDPs) do not shape into a stable and well-structured three-dimensional fold, while they are biologically active.It has been reported that many domains were disordered.Our research of domain disorder in the human proteome found that structural disorder ratios (SDR) of some protein domains in different contexts were obviously different.In this study, we try to explore the causes of the variation of domain structure disorder ratio (DSDR) and investigate the functional effects of the variation of DSDR.
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