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Effective control of insect pests and plant disease often depends on several complementary approaches that combine to form an integrated pest management strategy.Recent efforts to find new pesticides have not been able to prevent the evolution of resistance to insecticide treatment.The most successful insecticidal control method used to date has been the development of crops transformed with toxin genes of Bacillus thuringiensis(Bt).However,Bt toxins mostly target lepidopteran pests and have only been licensed in certain countries to control insect pests of corn and cotton.It is imperative that other non-insecticidal strategies be developed to alleviate the current reliance on chemical pesticides to protect environment and human health.One potential approach to this is to interfere with the ability of pest insects to find suitable mates and hosts which they do through volatile chemical signals(semiochemicals).Such olfaction-based approaches have been applied successfully in push-pull pest control strategy using plants which are capable of producing attractants and repellents.Recent studies at Rothamsted by JJZhous group now provide a starting point for the potential use of OBPs as targets to interfere with insect host location and mating behaviour.Such non-insecticidal approaches could play an important role as part of integrated pest management strategies and broaden the arsenal of available tools for insect pest control.I will introduce our basic and applied researches on the development of such alternative pests control strategy.