Tubulin-microtubule system is an important target for the development of anticancer drugs over the past decades because of its crucial involvement in mitosis.[1] In this paper,a series of novel chalco
Currently,there are 366 million people in the world affected diabetes mellitus,and the number may increase to 522 million by 20301a.a-Glucosidase inhibitors can delay the hydrolysis of carbohydrates,t
Human APOBEC3G(apolipoprotein B mRNA-editing enzyme,catalytic polypeptide-like 3G,A3G)is a potent restriction factor against human immunodeficiency virus type 1(HIV-1)by inducing hypermutation of G to
Diterpenoids,a largest group of natural products,are the focus of natural drug discovery due to their structural diversity and wide range of biological activities.Recently,as part of our continuing ef
Burkitts lymphoma(BL)is a highly aggressive non-Hodgkins lymphoma,with remarkable cell proliferation and metabolism.The oncogene c-Myc highly expresses in BL and plays a key role in facilitating tumor
A novel series of compounds were designed,synthesized and evaluated as multi-target-directed ligands against AD.2 The optimal compound of this series,18d,exhibited significant antioxidant effects(ORAC
Alzheimers disease(AD)is a multifaceted neurodegenerative disorder characterized by progressive cognitive decline and memory loss.Currently,more than 44 million people worldwide are believed to suffer