Synthesis of Xanthone Sulfonamides Derivatives as α-Glucosidase Inhibitors

来源 :2015年全国药物化学学术会议暨第五届中英药物化学学术会议 | 被引量 : 0次 | 上传用户:borchifish
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
  Currently,there are 366 million people in the world affected diabetes mellitus,and the number may increase to 522 million by 20301a.a-Glucosidase inhibitors can delay the hydrolysis of carbohydrates,thus reducing the level of postprandial plasma glucose.
其他文献
Breast cancer is one of the most common malignant tumor in women,both in the developed countries and developing countries.Triple-negative breast cancer(TNBC)refers to any breast cancer that does not e
Checkpoint kinase 1(Chk1)is a serine/threonine kinase that mediates cell cycle arrest in S-phase or at the G2/M transition.Inhibition of Chk1 would abrogate these checkpoints so that cancer cells,when
由于HIV-1 病毒不断出现的耐药性等问题,发展具有新结构和新作用机理的抗HIV-1 药物一直是艾滋病治疗的研究热点。近20 年前,人们发现一类DNA 四螺旋分子具有微摩尔水平的HIV-1 融合抑制活性,代表序列为Hotoda 等人发现的d(TGGGAG)。
目前肿瘤化疗存在的最大问题是缺乏选择性,化疗药物在杀死肿瘤细胞的同时对正常细胞造成极大伤害。解决抗肿瘤药物的靶向性和选择性,减少化疗的毒副作用,是肿瘤药物治疗领域需解决的世界性难题。
会议
As an endogenous insulinotropic hormone,Glucagon-like peptide-1(GLP-1)has tremendous potential in treating type Ⅱ diabetes.However,it will be rapidly inactivated by dipeptidyl peptidase Ⅳ(DPP-Ⅳ)at the
The RAF/MEK/ERK and PI3K/PDK/AKT are two of the most frequently dysregulated signaling cascades in human NSCLC,which are involved in the regulation of cell growth and survival.Molecular alterations in
Alzheimers disease(AD)is a fatal neurodegenerative disease with the deterioration of cognitive and memory functions.Homologous α7 nicotinic acetylcholine receptors have high calcium permeability,which
Nicotinic acetylcholine receptors(nAChRs)are members of Cys-loop ligand gated ion channels superfamily.The α7 nAChR,a homopentamer composed of five α7 subunits,has been implicated in diseases associat
Combretum caffrum(Combretaceae)是南非combretum属植物,从中分离出来一系列活性组分Combretastatins.其中以Combretastatin A-4(CA-4)的活性最好,其水溶性衍生物CA4P和AVE-8062目前已进入临床Ⅲ期,CA4P的二代衍生物CA1P亦进入了临床Ⅰ期试验阶段.
Tubulin-microtubule system is an important target for the development of anticancer drugs over the past decades because of its crucial involvement in mitosis.[1] In this paper,a series of novel chalco