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  5. Dual inhibition of RAF/MEK/ERK and PI3K/PDK/AKT signaling pathways with small molecules as anti-NSCL

Dual inhibition of RAF/MEK/ERK and PI3K/PDK/AKT signaling pathways with small molecules as anti-NSCL

来源 :2015年全国药物化学学术会议暨第五届中英药物化学学术会议 | 被引量 : 0次 | 上传用户：Lincon
【摘 要】
：
The RAF/MEK/ERK and PI3K/PDK/AKT are two of the most frequently dysregulated signaling cascades in human NSCLC,which are involved in the regulation of cell growth and survival.Molecular alterations in
【作 者】
：
Qianbin LI 
【机 构】
：
Department of Medicinal Chemistry,School of Pharmaceutical Sciences,Central South University,172 Ton
【出 处】
：
2015年全国药物化学学术会议暨第五届中英药物化学学术会议
【发表日期】
：
2015年3期
【关键词】
：
Dual inhibitors RAS/MEK/ERK PI3K/PDK/AKT Lung cancer 
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　　The RAF/MEK/ERK and PI3K/PDK/AKT are two of the most frequently dysregulated signaling cascades in human NSCLC,which are involved in the regulation of cell growth and survival.Molecular alterations in these pathways during the application of mono-pathway inhibitors lead to serious acquired resistance due to the cross-talk between two pathways.
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