【摘 要】
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The in vitro metabolism of an inverse agonist of the peripheral cannabinoid receptor (CB2), indomethaein morpholinylamide (BML-190), has been characterized using rat liver microsomal incubation.BML-19
【机 构】
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Department of Chemistry Director RCMI Cancer Research Program Xavier University of Louisiana USA
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The in vitro metabolism of an inverse agonist of the peripheral cannabinoid receptor (CB2), indomethaein morpholinylamide (BML-190), has been characterized using rat liver microsomal incubation.BML-190 was found to yield at least 15 rnetabolic products as identified by HPLC-MS/MS analysis.Four major phase one metabolic pathways either individually, or in combination, were proposed to account for the identified metabolic products: 1) loss of the p-chlorobenzyl group, 2) hydroxylation on the indole or on the morpholine ring, 3) morpholinyl ring opening, and 4) demethylation of the methoxyl group on the indole ring.
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