Pituitary Cells as Metabolic Sensors: The Importance of Leptin Feedback in Maintaining Optimal Body

来源 :2011年第一届内分泌与代谢大会 | 被引量 : 0次 | 上传用户：lixuechao0926

【摘要】

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【作者】

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Gwen V.Childs

【机构】

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Department of Neurobiology and Developmental Sciences College of Medicine University of Arkansas for

【出处】

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2011年第一届内分泌与代谢大会

【发表日期】

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2011年3期

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　　Leptin, the product of the Lep gene, reports levels of adiposity to the hypothalamus and other cells that regulate adiposity, including pituitary somatotropes, which secrete growth hormone (GH).It may also be involved in regulating gonadotropes, which secrete luteinizing hormone (LH) and follicle stimulating hormone (FSH).Global leptin or leptin receptor (LEPR) deficiency is associated with a decline in somatotrope and gonadotrope numbers, suggesting that leptin may be important in their maintenance.

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Pituitary Cells as Metabolic Sensors: The Importance of Leptin Feedback in Maintaining Optimal Body

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