【摘 要】
：
Integrins facilitate cell adhesion to extracellular matrix protein.These interactions confer resistance in tumor cells to ionizing radiation and chemotherapeutics, termed cell adhesion-mediated radior
【机 构】
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OncoRay-Center for Radiation Research in Oncology Dresden University of Technology Dresden Germany
【出 处】
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BIT‘s2nd Annual World Cancer Congess-2009 (2009第二届癌症大会)
论文部分内容阅读
Integrins facilitate cell adhesion to extracellular matrix protein.These interactions confer resistance in tumor cells to ionizing radiation and chemotherapeutics, termed cell adhesion-mediated radioresistance (CAM-RR) and cell adhesion-mediated chemoresistance (CAM-DR), substantially deteriorating therapy efficacy and patient survival.Identification of the molecular mechanisms by which integrins transduce their prosurvival signals in human squamous cell carcinoma cells of the head and neck (hHNSCC) pinpointed the critical role of integrins in the carcinogenesis of this tumor type.Applying inhibitory antibodies against different integrins, especially betal integrins, sensitized 3D grown hHNSCC tumor cells to X-rays.Conftrmatory data could be generated in xenografts models of hHNSCC cells in nude mice.Partly responsible for betal integrin-mediated radioresistance are interactions between the integral membrane protein Caveolin-1 and the epidermal growth factor receptor EGFR.These findings highlighted the presence of mutual cooperation between integrin and growth factor receptors for optimal regulation of critical cell functions such as survival, proliferation and apoptosis.Further in-vitro and in-vivo work is underway to evaluate betal integrin inhibition as general treatment option in malign human cancers.
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