Bioactive Evaluation and Cytotoxicity of Quinolones with Metronidazole

来源 :2015年全国药物化学学术会议暨第五届中英药物化学学术会议 | 被引量 : 0次 | 上传用户：lonlychanging

【摘要】

：

【作者】

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Rasheed SYED Sheng-Feng CUI Cheng-He ZHOU

【机构】

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Institute of Bioorganic & Medicinal Chemistry,Key Laboratory of Applied Chemistry ofChongqing Munici

【出处】

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2015年全国药物化学学术会议暨第五届中英药物化学学术会议

【发表日期】

：

2015年3期

【关键词】

：

Quinolone Metronidazole Imidazole DNA Antibacterial

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　　Hybrids of metronidazole and quinolones as antimicrobial agents were developed and their bioactive assay that the newly synthesized compounds exhibited good or even stronger antimicrobial activities against the tested strains including multi-drug resistant MRSA in comparison with reference drugs norfloxacin,chloromycin and fluconazole.Cell toxicity disclosed that highly active target compounds did not show toxicity to A549 cell line within the concentration of 256 μg/mL.

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Bioactive Evaluation and Cytotoxicity of Quinolones with Metronidazole

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