Objective To synthesize the important intermediates of Olmesartan.Methods 2-propyl-1H-imidazole-4,5-dicarboxylic acid diethyl ester was synthesized using tartaric acid,an easily available,inexpensive
Aims: Afatinib is a potent,irreversible and double tyrosine kinases inhibitor of EGFR and HER2,so we target is to synthesis and optimize the synthesis technology of afatinib and make it more suitable
Aims:NVP-BEZ235 is the development of a Novartis ATP competitive inhibition of PI3K/mTOR anticancer drug and inhibition the catalytic activity of Akt and mTOR.This paper introduces the research progre
Vandetanib(1)is a kind of tryrosine kinase inhibitors.It is a potent inhibitor of VEGF RTK and also has some activity against epidermal growth factor(EGF)RTK[1].It inhibits the effects of VEGF and is
c-Met is a proto-oncogene that encode a protien known as hepatocyte growth factor receptor(HGFR)[1].Inappropriate activity of c-Met can cause wide variety of different cancers such as breast,pancreas,
Hemagglutinin(HA)which is essential for influenza viral infection and replication has become a target for the design of anti-influenza drugs.A novel series of oligothiophene compounds focused on the t
Chiral BINOL-based phosphoric acids are an array of privileged and bifunctional organocatalysts,the activities of which have been successfully demonstrated in a variety of organic transformations.[1]