新型核苷类抗肿瘤药物的合成研究

来源 :2015年全国药物化学学术会议暨第五届中英药物化学学术会议 | 被引量 : 0次 | 上传用户：sin4x

【摘要】

：

核苷类似物是一类重要的抗肿瘤和抗病毒药物。核苷类抗肿瘤药物的研究表明，通过改变分子糖基侧链可以使药物的抗肿瘤活性有很大的提高，同时还可以降低药物的毒副作用。由于氟原子的体积小且具有强烈的电负性，能参与氢键作用，因此在核苷的糖基上连接氟原子会影响整个核苷结构的电子分布，使其化学稳定性增加。

【作者】

：

李伟温新民

【机构】

：

济宁医学院药学院,日照,276826

【出处】

：

2015年全国药物化学学术会议暨第五届中英药物化学学术会议

【发表日期】

：

2015年3期

【关键词】

：

核苷类似物抗肿瘤合成

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新型核苷类抗肿瘤药物的合成研究

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