Human dihydroorotate dehydrogenase(hsDHODH),a flavin-dependent mitochondrial enzyme,plays a rate-limiting role in pyrimidine de novo biosynthesis,which has been identified as a potential target for th
Drug-induced hepatotoxicity is a leading cause of acute liver failure worldwide and one of the most frequent reasons for the withdrawal of approved drugs from the market.[1-2] Thus,drug-induced hepato
Diabetes,as a chronic metabolic disorder,has become the third major disease threatening the health of human being,and type 2 diabetes mellitus(T2DM)accounts for 90%of cases diabetes.Diabetes patients
SETD8/SET8/Pr-SET7/KMT5A is the sole protein lysine methyltransferase(PKMT)that catalyzes the monomethylation of histone H4 lysine 20(H4K20).[1] Because of the diverse biological functions of SETD8,th
The number of bacterial strains resistant to antimicrobial agents is continuously increasing,thus warranting the rapid development of new drugs with novel mechanisms of killing bacterial cells1.
Estrogen receptor is involving in hormone-regulated cancer and Alzheimer.There are two subtypes of ER,ERα and ERβ,the function of which are up-or down-regulating the related gene expression in target
Series of N-substituted benzylidene aromatic amine were synthesized.Their structures were characterized by NMR spectrum.Some crystal structures were refined through the SHELXL97 software processing.