Synthesis and process optimization of Vandetanib

来源 :2015年全国药物化学学术会议暨第五届中英药物化学学术会议 | 被引量 : 0次 | 上传用户：koala_zz

【摘要】

：

Vandetanib(1)is a kind of tryrosine kinase inhibitors.It is a potent inhibitor of VEGF RTK and also has some activity against epidermal growth factor(EGF)RTK[1].It inhibits the effects of VEGF and is

【作者】

：

Wang Min WuFu Zhu

【机构】

：

School of Pharmacy,Jiangxi Science & Technology Normal University,Nanchang 330013,China

【出处】

：

2015年全国药物化学学术会议暨第五届中英药物化学学术会议

【发表日期】

：

2015年3期

【关键词】

：

Vandetanib tryrosine kinase inhibitor Synthesis

下载到本地 , 更方便阅读

下载此文赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

　　Vandetanib(1)is a kind of tryrosine kinase inhibitors.It is a potent inhibitor of VEGF RTK and also has some activity against epidermal growth factor(EGF)RTK[1].It inhibits the effects of VEGF and is of interest for its antiangiogenic and/or vascular permeability effect[2-3].

其他文献

Design and synthesis of novel pyrimidine-amide conjugates

Pyrimidines play an important role in the drug discovery process,and have considerable pharmacological and chemical significance.[1] Pyrimidines have been recognized as important heterocyclic compound

会议

pyrimidineamidesynthesispharmacologicalanticancer

Molecular Modeling Studies of G-Protein-Coupled Receptor 30

Breast cancer(BC)is a molecularly heterogeneous disease still remaining a leading cause of women death in many countries.Reportedly,approximately 50% of breast cancer patients express GPR30,which is c

会议

G-protein-coupled receptor (GPCR)GPR30homology modelingbreast cancer

Synthesis of 5-substituted oxazolidinones

The totally-synthetic oxazolidinones,named by linezolid [1],are a new class of antibacterial agents for the treatment of the infections caused by Gram-positive bacteria.researches have been conducted,

会议

oxazolidinonelinezolidsynthesis

Synthesis and biological evaluation of homoserine lactone derivatives as inhibitors of quorum sensin

The Pseudomonas aeruginosa quorum-sensing(QS)molecule N-(3-oxododecanoyl)-L-homoserine lactone is involved not only in bacterial activation but also in subversion of the host immune system.

会议

quorum sensing inhibitorssynthesisactivity

Design,Synthesis and Biological Evaluation of a novel class of steroidal 1,4-Androstadiene-3,17-dion

Steroids are a class of important multi-cyclic compounds which exhibit diverse biological activities.Several steroidal derivatives have been investigated as new curative agents for cancers and other d

会议

14-Androstadiene-317-dioneD-ring modificationvinylogous addition

新型核苷类抗肿瘤药物的合成研究

核苷类似物是一类重要的抗肿瘤和抗病毒药物。核苷类抗肿瘤药物的研究表明，通过改变分子糖基侧链可以使药物的抗肿瘤活性有很大的提高，同时还可以降低药物的毒副作用。由于氟原子的体积小且具有强烈的电负性，能参与氢键作用，因此在核苷的糖基上连接氟原子会影响整个核苷结构的电子分布，使其化学稳定性增加。

会议

核苷类似物抗肿瘤合成

A method for synthesis of the important intermediates of Olmesartan

Objective To synthesize the important intermediates of Olmesartan.Methods 2-propyl-1H-imidazole-4,5-dicarboxylic acid diethyl ester was synthesized using tartaric acid,an easily available,inexpensive

会议

2-propyl-1H-imidazole-45-dicarboxylic acid diethyl esterintermediates of Olmes

Synthesis and process optimization of antitumor agent afatinib

Aims: Afatinib is a potent,irreversible and double tyrosine kinases inhibitor of EGFR and HER2,so we target is to synthesis and optimize the synthesis technology of afatinib and make it more suitable

会议

Double tyrosine kinases inhibitorAfatinibIndustrializationSynthesis

Design,synthesis and evaluation of novel furanone quorum sensing inhibitors in Pseudomonas aeruginos

会议

Synthesis and Process Optimization of Antitumor Agent NVP-BEZ235

Aims:NVP-BEZ235 is the development of a Novartis ATP competitive inhibition of PI3K/mTOR anticancer drug and inhibition the catalytic activity of Akt and mTOR.This paper introduces the research progre

会议

PI3K/mTOR inhibitorNVP-BEZ235IndustrializationSynthesis

Synthesis and process optimization of Vandetanib

其他学术论文