Synthesis and process optimization of antitumor agent afatinib

来源 :2015年全国药物化学学术会议暨第五届中英药物化学学术会议 | 被引量 : 0次 | 上传用户：LittleCam

【摘要】

：

Aims: Afatinib is a potent,irreversible and double tyrosine kinases inhibitor of EGFR and HER2,so we target is to synthesis and optimize the synthesis technology of afatinib and make it more suitable

【作者】

：

Y.B.TU M.WANG W.H.WANG L.CHEN P.W.ZHENG W.F.ZHU

【机构】

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School of Pharmacy,Jiangxi Science & Technology Normal University,Nanchang 330013,China

【出处】

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2015年全国药物化学学术会议暨第五届中英药物化学学术会议

【发表日期】

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2015年3期

【关键词】

：

Double tyrosine kinases inhibitor Afatinib Industrialization Synthesis

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　　Aims: Afatinib is a potent,irreversible and double tyrosine kinases inhibitor of EGFR and HER2,so we target is to synthesis and optimize the synthesis technology of afatinib and make it more suitable for industrialization.

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Synthesis and process optimization of antitumor agent afatinib

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