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  5. The selective BACE1 inhibitor Vla reduces Aβ production and ameliorates behavioral deficits in a mou

The selective BACE1 inhibitor Vla reduces Aβ production and ameliorates behavioral deficits in a mou

来源 :The 12th Meeting of the Asia Pacific Federation of Pharmacol | 被引量 : 0次 | 上传用户：ZLF308440423
【摘 要】
：
Aim: We are pursuing potent BACE1 inhibitors in an effort to identify suitable AD drug candidates.Methods: Employing a homogeneous, time-resolved fluorescence (hTRF) technique, we determined the selec
【作 者】
：
Xiao-rui CHENG Yu ZHOU Wei GU Ai-hua NIE Jun-ping CHENG Jin-wu ZHOU Wen-xia ZHOU Yong-xiang ZHANG 
【机 构】
：
Beijing Institute of Pharmacology and Toxicology, Beijing 100850,China
【出 处】
：
The 12th Meeting of the Asia Pacific Federation of Pharmacol
【发表日期】
：
2013年4期
【关键词】
：
β-site APP cleaving enzyme 1 β-amyloid inhibitor Alzheimer's disease 
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Aim: We are pursuing potent BACE1 inhibitors in an effort to identify suitable AD drug candidates.Methods: Employing a homogeneous, time-resolved fluorescence (hTRF) technique, we determined the selectivity of compound Via.We then conducted a cell-based assay using the huAPPswe/huBACE1 transgenic CHO cells to investigate the effect on the β-cleavage of APP.
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